Our vision is our passion: AFFiRiS is dedicated to developing novel disease-modifying immunotherapies for neurodegenerative diseases. From brains for brains. From us for you.


AFFiRiS is a clinical-stage biopharmaceutical company that pursues the ultimate aim to improve the lives of patients suffering from neurodegenerative diseases by providing disease-modifying specific active immunotherapies (SAIT) based on its proprietary patented AFFITOME® technology.

We strive to deliver much‑needed therapies to patients with debilitating and life‑threatening neurodegenerative diseases, such as Parkinson’s disease, multiple system atrophy (MSA), dementia with Lewy Bodies (DLB), and Huntington’s disease.

We aim to surpass currently available treatments.

We focus on unmet medical needs in neurodegenerative diseases

Neurodegenerative diseases can have devastating effects on the quality of life of patients and family members, and often worsen over time. Currently available treatments for many of these diseases aim to manage symptoms, and do not stop or reverse progression. As a result, neurodegenerative diseases often lead to a progressively reduced quality of life. Therefore, better treatments for neurodegenerative diseases are needed to give patients healthier, happier, and longer lives.
We embrace this opportunity.




Specific Active ImmunoTherapy (SAIT)

Adherence to current therapies can be poor due to complex dosing regimens, and the treatment of many neurodegenerative diseases is stillinadequate. Using our unique AFFITOME technology, we are developing Specific Active ImmunoTherapy (SAIT), which stimulates the body to find and fight proteins central to the development and progression of neurodegenerative diseases. SAIT induces a long‑lasting target-specific immune response, which may be generated by far less frequent dosing regimens (e.g. once or twice a year)
SAIT is an exciting prospect.

Our pipeline

We focus on identifying proteins that are involved in the development and progression of neurodegenerative diseases, and establishing novel SAIT treatments against pathogenic forms of these proteins using our unique AFFITOME technology. SAIT has successfully demonstrated proof of concept in both preclinical and clinical studies. Our most advanced product candidates are entering Phase II clinical trials.
We are moving forward.





We intensively collaborate with a range of companies, universities, and foundations during the development of our novel SAIT treatments.
Be part of our journey.


We have a broad portfolio of immunotherapies that can be used in the treatment of a variety of neurodegenerative diseases, supported by a range of companies.
Partner with us.

Contact us